5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate -

Description

Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.

Product Details

Catalog NoN-2060

Purity≥90% by AX-HPLC

Extinction Coefficient7,700 Lmol-1cm-1 at 275 nm

Molecular FormulaC10H18N3O14P3 (free acid)

Molecular Weight497.10 g/mole (free acid)

Salt FormLi+

Concentration100 mM

BufferH2O

Recommended Storage-20°C or below

Other Name(s)5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP

ApplicationAptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies

Backbone5'-Triphosphate

Base Analog(s)Cytidine

Sugar Type(s)DNA

Nucleotide CategoryBase Modified DNA