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Bortezomib蛋白酶体抑制剂

更新时间:2023-01-31   点击次数:338次

产品名称:Bortezomib

产品描述:蛋白酶体抑制剂

产品货号:SIH-328

纯度:>98%

CAS号:179324-69-7

分子式:C19H25BN4O4

分子量:384.2


产品特性


储存温度:-20ºC

运输温度:常温运输

产品类型:抑制剂

溶解性:溶解于DMSO (50mg/mL), 乙醇 (35mg/mL )

来源:合成的

性状:白色粉末

SMILES:B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

InChIInChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

InChIKey:GXJABQQUPOEUTA-RDJZCZTQSA-N

安全术语:安全级别: 注意: 物质尚未充分测试. 安全术语: S22 -不要吸入粉尘 S36/37/39 - 穿戴适当的防护服、手套和眼睛/面部保护 S24/25- 避免皮肤和眼睛接触

引用该产品:Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328)


生物学特性


别名:Bortezomib, 保特佐米, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol

研究领域:癌症, 细胞凋亡, 肿瘤生长抑制剂, 蛋白酶体抑制剂

PubChem ID:387447

科研背景:Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.

参考资料:1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.


订购详情

品牌产品名称产品货号规格
StressmarqBortezomibSIH-328-25MG25MG
StressmarqBortezomibSIH-328-5MG5MG


文献引用


Extracellular vesicles drived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts.

Dieude, M. et al. (2019) Am J Transpl 20(3):726-738.

PubMed ID: 31729155 应用范围: In vitro inhibition


The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

Dieude, M. et al. (2019) Sci Transl Med 7(318)

PubMed ID: 26676607 应用范围: In vitro inhibition



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