血管紧张素ⅡELISA试剂盒产品介绍--Enzo Life Sciences热销产品

血管紧张素是来源于血管紧张素原的小肽。几种已知的血管紧张素是调节血压的既定内分泌效应物，但它们也已知在一些器官和组织（旁分泌）和细胞水平（自分泌/内分泌）具有其他局部功能。血管紧张素I(DRVYIHPFHL)没有已知的效应器功能，但它是血管紧张素II(DRVYIHPF)的直接前体。血管紧张素II与AT1受体结合，促进血管收缩、钠潴留、醛固酮的释放、氩加压素的释放、细胞增生、炎症、纤维化、焦虑和心脏肥大。血管紧张素A(ARVYIHPF)，和血管紧张素III(RVYIHPF)，也与AT1受体结合。血管紧张素(1-7)(DRVYIHP)结合不同的受体，称为MAS-1，具有相反的作用（血管扩张、利尿、抗扩散、NO释放、PGE释放和细胞凋亡）。血管紧张素IV(VYIHPF)与另一个称为AT4(IRAP)的受体结合，促进血流增加、血管生成和利尿，它也与记忆的形成和阿尔茨海默病的发病机制有关。肽LVV-hemorphin-7（LVVYPWTQRF）不是血管紧张素，但也能与AT4受体结合。还有其他已经确定的血管紧张素肽，包括Ang(1-9)(DRVYIHPFH)、Ang(1-12)(DRVYIHPFHLVI)、Ang V(3-7)(VYIHP)，以及其他几种功能未定的短肽。

ENZO Angiotensin II ELISA kit是一种比色竞争法免疫检测试剂盒，3.5小时内即可得到结果。

● 高度特异性，与类似肽交叉反应性低

● 超越半定量Western blot分析的全定量检测

● 易于使用的液体颜色编码试剂，最大限度地减少错误

● 即用型试剂和预包被板可减少错误并节省您的时间

产品信息

部分产品引用文献

1. ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury: T. Minato, et al.; PLoS One 17, e0270920 (2022)

2. Maternal perfluorooctane sulfonic acid exposure during rat pregnancy causes hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in the uterine arteries: S.V. Dangudubiyyam, et al.; Biol. Reprod. 107, 1072 (2022)

3. Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP): M. Nishikawa, et al.; Toxicol. Rep. 9, 256 (2022)

4. Vasorin plays a critical role in vascular smooth muscle cells and arterial function: L. Louvet, et al.; J. Cell. Physiol. 237, 3845 (2022)

5. ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury: T. Yamaguchi, et al.; Nat. Commun. 12, 6791 (2021)

6. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling: K. Xue, et al.; Oxid. Med. Cell. Longev. 2021, 5710440 (2021)

7. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)

8. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction: T. Minato, et al.; Nat. Commun. 11, 1058 (2020)

9. Diabetes-induced Upregulation of Kallistatin Levels Exacerbates Diabetic Nephropathy via RAS Activation: Y. Yang, et al.; FASEB J. 34, 8428 (2020)

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