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ENZO热销产品——Leptin (mouse) ELISA kit

更新时间:2023-06-20   点击次数:267次

瘦素(Leptin)是由ob基因编码、在脂肪组织中生成的一种脂肪代谢调控产物,在代谢和调控体重等方面发挥重要作用。它通过下丘脑中的瘦素受体发出信号,降低食欲,增加能量消耗。在外周组织中,瘦素能拮抗胰岛素信号传导,增加脂肪酸氧化,减少胰岛β细胞的胰岛素分泌,并促进生育。它在脂肪细胞中的表达可以被其他脂肪因子如IL-6(刺激)和TNF-α(抑制)以旁分泌方式调节。瘦素缺乏的小鼠表现出严重的胰岛素抵抗、肥胖和生育能力下降,所有这些都可以通过外源性瘦素给药而逆转。还有研究表明,瘦素与心血管疾病有关,因为它介导了许多促炎和促动脉粥样硬化作用,如内皮素-1(ET-1)表达增加、活性氧(ROS)积累、单核细胞趋化蛋白-1(MCP-1)分泌以及交感血管张力和血压增加。

 

● 灵活:适用于正常和病理样本

● 高灵敏:可检测<26 pg/ml的小鼠瘦素水平

● 快速:仅需3小时就可获得39个样本的重复结果

● 方便:预包被板和即用型试剂为您节省实验时间

 

ENZO热销产品——Leptin (mouse), ELISA kit 

 

产品信息

产品货号

ADI-900-019A

产品名称

Leptin (mouse), ELISA kit(小鼠瘦素ELISA试剂盒)

规格

96 wells

灵敏度

25.4 pg/ml

检测范围

50-3,200 pg/ml

检测时间

3 hours

样本种属

Mouse

样本类型

culture supernatants, plasma, and serum. 

Cited sample type includes tissue

保存温度

+4°C

试剂盒组分

Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28, 

TMB Substrate, Stop solution 2, Wash buffer concentrate


部分产品引用文献

1. High salt diet does not impact the development of acute myeloid leukemia in mice: M. Janakiraman, et al.; Cancer Immunol. Immunother. 72, 265 (2023)

2. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress: L. Morató, et al.; Sci. Adv. 8, eabj9109 (2022) 

3. Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism: B.S. Smith, et al.; Int. J. Obes. 46, 1446 (2022)

4. The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue: C. Peres Valgas da Silva, et al.; Clin. Exp. Pharmacol. Physiol. 48, 1477 (2021)

5. Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism: M. Woo, et al.; Mar. Drugs 16, 306 (2018) 

6. Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice: I.H. Kim, et al.; Int. J. Mol. Med. 41, 924 (2018), Application(s): ELISA using mouse serum 



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