技术文章您现在的位置:首页 > 技术文章 > BioXcell热销产品InVivoMab anti-mouse CD28/小鼠CD28单克隆抗体

BioXcell热销产品InVivoMab anti-mouse CD28/小鼠CD28单克隆抗体

更新时间:2023-07-05   点击次数:253次

BioXcell热销产品InVivoMab anti-mouse CD28/小鼠CD28单克隆抗体


产品描述:


The 37.51 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. The 37.51 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells and provide a costimulatory signal for CTL induction.


BioXcell InVivoMab anti-mouse CD28 37.51单克隆抗体与小鼠CD28反应,CD28是一种45kDa的共刺激受体,也是Ig超家族的一员。CD28由胸腺细胞,大多数外周T细胞和NK细胞表达。CD28是CD80(B7-1)和CD86(B7-2)的受体。通过CD28的信号传导增强了IL-2和IL-2受体的表达以及CD3活化的T细胞的细胞毒性。37.51抗体已被证明能刺激活化的T细胞和NK细胞的增殖和细胞因子的产生,并为CTL诱导提供共刺激信号。

BioXcell热销产品--InVivoMab anti-mouse CD28 


产品详情:

产品名称

InVivoMAb anti-mouse CD28

产品货号

BE0015-1

产品规格

1/5/25/50/100mg

反应种属

Mouse

克隆号

37.51

同种型

Syrian Hamster IgG2

免疫原

C57BL/6 mouse T cell lymphoma EL-4 cells

实验应用

in vitro T cell stimulation/activation

in vivo CD28 blockade

产品形式

PBS, pH 6.0 0.01% Tween,Contains no stabilizers or preservatives

纯度

>95%, Determined by SDS-PAGE

无菌处理

0.2 µm filtration

纯化方式

Protein G

RRID

AB_1107624

分子量

150 kDa

保存条件

抗体原液保存在4°C,不能冷冻保存。

推荐同型对照

InVivoMAb polyclonal Syrian hamster IgG(货号BE0087)

推荐抗体稀释液

InVivoPure pH 6.0T Dilution Buffer(货号IPT060)

 

 该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:


应用

文章

体外T细胞刺激/激活

(in vitro T cell stimulation/activation)

1. Lacher, S. M., et al. (2018). 'NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling' J Autoimmun 94: 110-121.

2. Wendland, K., et al. (2018). 'Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis' J Immunol 201(2): 524-532.

3. Ron-Harel, N., et al. (2016). 'Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation' Cell Metab 24(1): 104-117.

4. Gu, A. D., et al. (2015). 'A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling' Immunity 42(1): 68-79.

5. Choi, Y. S., et al. (2015). 'LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6' Nat Immunol 16(9): 980-990.  

体内CD28阻断

(in vivo CD28 blockade)

1. Rouhani, S. J., et al. (2015). 'Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction' Nat Commun 6: 6771.

2. Eberlein, J., et al. (2012). 'Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity' J Virol 86(4): 1955-1970.

 

 

BioXcell热销产品--InVivoMab anti-mouse CD28


更多产品详情请联系 BioXcell 中国授权代理——欣博盛生物