Ganglioside GT1b . trisodium salt (bovine brain)

更新时间：2022-01-27

简要描述：

Ganglioside GT1b . trisodium salt (bovine brain)， Prevents neurotoxicity of glutamate on neuronal cells.

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Ganglioside GT1b . trisodium salt (bovine brain)

Product Details

Alternative Name:	GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain)

Sequence:	[II³(Neu5Ac)2, IV³(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer]

Formula:	C95H162N5O47 . 3Na

MW:	2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)

CAS:	59247-13-1

Purity:	≥98% (TLC)

Appearance:	White solid.

Solubility:	Soluble in chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water.

Shipping:	Ambient

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci. 11, 74 (2010), Abstract;

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS 85, 7351 (1988), Abstract;

General Literature References

Botulinum neurotoxin: a marvel of protein design: M. Montal; Annu. Rev. Biochem. 79, 591 (2010), Abstract; Full Text

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