MPLA-SM

Monophosphoryl Lipid A from Salmonella minnesota R595

Monophosphoryl Lipid A (MPLA-SM) is extracted from lipopolysaccharide (LPS or endotoxin) produced by the Re mutant of a rough strain Salmonella minnesota R595.

Specifications

Species: Salmonella enterica serovar minnesota mutant R595

Specificity: TLR4 agonist

Working concentration: 10 ng - 1 μg/ml

Endotoxin level: > 0.5  x 10⁶ EU/mg

Appearance: Clear lipidic film

Solubility: 1 mg/ml in DMSO

Contents

MPLA-SM is provided as a clear, lyophilized lipidic film.

• 1 mg Monophosphoryl Lipid A (MPLA-SM)

 MPLA-SM is shipped at room temperature.

 Store at -20°C. Upon resuspension, prepare aliquots of MPLA and store at -20°C.

 Product is stable 6 months at -20°C.

 Avoid repeated freeze-thaw cycles.

Description

MPLA-SM is a potent activator of TLR4 with negligible TLR2 activity. MPLA-SM was extracted from LPS using treatment with acid and heat followed by chromatography. Preparations of natural MPLA, such as MPLA-SM, contain a mixture of 5, 6, and 7 acyl lipid A [1].

Note: Due to the intrinsic structural complexity of lipid A, some batch-to-batch variation may occur.

1. Qureshi n. et al., 1985. Monophosphoryl lipid A obtained from lipopolysaccharides of Salmonella minnesota R595. Purification of the dimethyl derivative by high performance liquid chromatography and complete structural determination. J. Biol. Chem. 260, 5271–8.

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