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MPLA-SM

更新时间:2022-01-29

简要描述:

Monophosphoryl Lipid A from Salmonella minnesota R595
Monophosphoryl Lipid A (MPLA-SM) is extracted from lipopolysaccharide (LPS or endotoxin) produced by the Re mutant of a rough strain Salmonella m…

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Monophosphoryl Lipid A from Salmonella minnesota R595

Monophosphoryl Lipid A (MPLA-SM) is extracted from lipopolysaccharide (LPS or endotoxin) produced by the Re mutant of a rough strain Salmonella minnesota R595.


Specifications

Species: Salmonella enterica serovar minnesota mutant R595

Specificity: TLR4 agonist

Working concentration: 10 ng - 1 μg/ml

Endotoxin level: > 0.5  x 106 EU/mg

Appearance: Clear lipidic film

Solubility: 1 mg/ml in DMSO


Contents

MPLA-SM is provided as a clear, lyophilized lipidic film.

  • 1 mg Monophosphoryl Lipid A (MPLA-SM)

room temperature MPLA-SM is shipped at room temperature.

store Store at -20°C. Upon resuspension, prepare aliquots of MPLA and store at -20°C.

stable Product is stable 6 months at -20°C.

Alert Avoid repeated freeze-thaw cycles.


Description

MPLA-SM is a potent activator of TLR4 with negligible TLR2 activity. MPLA-SM was extracted from LPS using treatment with acid and heat followed by chromatography. Preparations of natural MPLA, such as MPLA-SM, contain a mixture of 5, 6, and 7 acyl lipid A [1].

Note: Due to the intrinsic structural complexity of lipid A, some batch-to-batch variation may occur.

1. Qureshi n. et al., 1985. Monophosphoryl lipid A obtained from lipopolysaccharides of Salmonella minnesota R595. Purification of the dimethyl derivative by high performance liquid chromatography and complete structural determination. J. Biol. Chem. 260, 5271–8.


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