产品中心您现在的位置:首页 > 产品展示 > > 天然免疫研究产品 > MDP

MDP

更新时间:2022-01-29

简要描述:

Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines.
MDP has been shown to be recognized by…

型号:厂商性质:代理商浏览量:85

NOD2 Agonist - Muramyldipeptide (L-D isomer, active)

Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines.

MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1, 2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs [2].

The potent adjuvant activity of MDP may be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3].

 

References:

1. Girardin SE. et al., 2003. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem. 278(11):8869-72.
2. Inohara N. et al., 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.J Biol Chem. 278(8):5509-12.
3. Martinon F. et al., 2004. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol. 14(21):1929-34.


Specifications

Specificity: NOD2 agonist

Working concentration: 10 ng - 10 µg/ml

CAS number: 53678-77-6

Solubility: 10 mg/ml in water

Formula: C19H32N4O11

Molecular weight: 492.5

Synonym: N-Acetylmuramyl-L-Alanyl-D-Isoglutamine (L-D isoform)


Contents

MDP is provided as a lyophilized powder.

  • 5 mg Muramyl dipeptide (MDP)

  • 2 ml sterile endotoxin-free water

room temperature MDP is shipped at room temperature.

store Store at -20°C. Upon resuspension, aliquote MDP and store at -20°C. 

stable Product is stable 6 months at -20°C when properly stored.

Alert Avoid repeated freeze-thaw cycles.


如需购买或咨询该产品技术问题,请联系Invivogen一级代理商--欣博盛生物

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
在线咨询
在线客服